Ocean Blue The HIV AIDS Vaccines Ethics Group

The HIV AIDS Vaccines Ethics Group

Addressing ethical legal complexities in HIV vaccine trials in South Africa


Welcome to HAVEG

Latest Project

Trials of experimental HIV vaccines with human participants are being conducted in various parts of the world, including South Africa. Such trials form part of efforts to develop new prevention tools to add to a ‘combination prevention’ toolbox for at-risk populations.

Such trials are ethically complex, in part because they involve actors from high-income settings working in collaboration with those from more resource-constrained settings, and because participants may have several vulnerabilities, such as low research literacy, impoverishment or marginalization, that may increase risk of trial-related harms or make consent decisions complex.

Such trials must adhere to national and international ethical guidelines for their design and implementation to ensure that participants’ welfare is promoted while they contribute to research designed to generate knowledge and products that may assist future beneficiaries.